… approaches to induce fetal hemoglobin (HbF) to treat sickle … progenitors into a fetal-like state
and thereby elevate HbF levels, … during the ontogeny of human erythropoiesis, such that at …

… to HUDEP2 cells and mature adult erythrocytes (supplemental Figure … F cells represent a
return to a fetal-like state, we carried out … in a heterocellular fashion in vivo and ex vivo by poorly …

… sickling of cultured mature erythrocytes from pediatric patients … expression of LIN28B as the
hallmark of a novel fetal-like … -expression had only minor effects in ex vivo erythropoiesis and …

… data, we show that in erythropoiesis the expression of the … of fetal origin (JMML), characterized
by high fetal hemoglobin … LIN28B in different human fetal-like erythroid cell types and in …

… ) expression in human erythroblasts derived ex vivo from fetal … fetal hemoglobin (HbF) as
the main hemoglobin produced by … and production of fetal-like erythrocytes from adult human …

… ε-globin that is found in the transient primitive erythrocyte … for fetal hemoglobin and (C)
HBB genes for adult hemoglobin at … to have global roles in erythropoiesis and hematopoiesis. …

… that maintaining fetal hemoglobin (HbF) at levels above 30% in circulating red cells should …
Transductions were performed in CD34(+) cells from adult healthy volunteers cultured ex vivo …

… erythropoiesis by increasing γ-globin and fetal hemoglobin (… HU on the reactivation of fetal
hemoglobin, we examined the … , a heightened HbF expression in cultured red blood cells was …

… of the switch from fetal to adult hemoglobin gene expression; (2) … to both HbF-containing
and non–HbF-containing erythrocytes. … expressed in F-erythroblasts compared with non–HbF-…

… promoters during adult erythropoiesis (38). … human erythroid progenitors. We further
showed the ability of MIR29B to induce HbF and reduce red blood cell sickling without producing …